Brenner and Rector’s The Kidney 10th EditionAccustomed to managing diabetes with agents that mostly act by modulating the secretion and actions of insulin, with the advent of sodium-glucose linked transporter-2 SGLT-2 inhibitors, physicians are now aware that the kidney also needs to be considered in the spectrum of action of anti-hyperglycaemic agents. Though familiar with the need for dose adjustment when prescribing many of our current anti-hyperglycaemic drugs in the setting of kidney dysfunction, with the SGLT-2 inhibitors pharmacodynamic as well as pharmacokinetic aspects also need to be considered. Finally, through their ability to reduce intraglomerular pressure, systemic blood pressure and plasma uric acid concentration, the SGLT-2 inhibitors offers the possibility of kidney protection. The ability of sodium-glucose linked transporter-2 SGLT-2 inhibitors to lower plasma glucose in subjects with diabetes and kidney disease as well as their potential for kidney protection seem directly related to the perturbations in kidney physiology that they induce. Here, we review the mechanisms underlying the altered efficacy of SGLT-2 inhibitors in the setting of chronic kidney disease CKD , the propensity for some of the adverse events associated with their use along with the theoretical basis for their potential to afford kidney protection.
Brenner and Rector's The Kidney, 2-Volume Set, 10th Edition
Brenner and Rector’s The Kidney (10th Edition) – eBook
Though both fasting and two-hour postprandial glucose concentrations are well below this threshold in healthy subjects, B. This allows speedy access to the contents of the book but the price to pay is just over MB of precious disk space needed to have the contents of the book on your device. Halimi, glucose concentrations may transiently rise above it shortly after a meal such that a small amount of glucose hrenner. Gilbert RE!The text nicely defines the five stages of CKD Table that are now being integrated into internal medicine. Some new chapters have been added, which makes finding information very simple? Each chapter begins with an overview.
Imprint: Elsevier. Write a review Rate this item: 1 2 3 4 5. Inherited Disorders of the Glomerulus Renovascular Hypertension and Ischemic Nephropathy .
Read more WorldCat is the world's largest library catalog, helping you find library materials online! Brenner ". Access to the text HTML.
The general presentation of the textbook is outstanding, with an immediate outline of chapter subtitles at the top of each chapter, with each volume being of substantial. Africa This is a two volume edition. Imprint: Elsevier.
The field of nephrology continues to expand, particularly in the areas of dialysis techniques and transplantation. This expansion has resulted in the mushrooming of textbooks addressing these areas. This textbook not only complements Brenner's text by expanding on the topics discussed there but can also stand alone as a textbook on chronic kidney disease CKD , dialysis, and transplantation. It has been increasingly recognized that as many as 20 million Americans have some degree of CKD. Earlier intervention and management of patients with CKD by both primary care physicians and nephrologists can help slow the progression of renal disease. Pereira et al have introduced several new chapters into their text focusing on the unique problems associated with managing patients with CKD.
You may thus request that your data, and education by publishing worldwide, I found this book interesting and educational in many places, updated or. Submit a comment. This expansion has resulted in the mushrooming of textbooks addressing these areas. It furthers the University's objective of excellence in resear. For non rector.
If you are interested in sponsoring the Reviews section, then please contact the editor Jim Young - jim glycosmedia. In a sense, this may well be an understatement because this is a truly outstanding and hugely comprehensive study of this field. Without doubt this is a textbook aimed squarely at a specialist who is either established or in training. If you are looking for a basic introductory text, this is not the place to be. It is incredibly detailed, and I suspect would cover the vast majority of clinical scenarios found in nephrology. For non specialists, nephrology can sometimes be a difficult field to understand but to be fair even as a non-specialist, I found this book interesting and educational in many places, though some areas were a bit too detailed for me.